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Zetia is contraindicated in the following conditions .
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Caution should be exercised when using ZETIA and cyclosporine concomitantly due to increased exposure to both ezetimibe and cyclosporineCyclosporine concentrations should be monitored in patients receiving ZETIA and cyclosporine.
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Dujovne et al performed a multicenterrandomizeddouble-blindplacebo-controlled study to evaluate the safety and efficacy of ezetimibe 10 mg in 892 patients with primary hyper-cholesterolemiaThese patients had previously been treated with lipid-lowering agentsbile acid sequestrantsnicotinic acidfibratesand/or statinsEzetimibe 10 mg or placebo was administered daily for a period of 12 weeksThe primary efficacy endpoint was the percentage reduction in direct plasma overseasrxdrugs coupon. LDL cholesterol from baselineSecondary endpoints included changes and percentage changes from baseline in LDL cholesterol calculated by the Friedewald equationtotal cholesteroltriglycerideand HDL cholesterol levels over time and at endpointand changes from baseline in HDL cholesterol subfractions HDL 2 cholesterol and HDL 3 cholesterolapolipoprotein A-Iapolipo-protein Band lipoproteinaat endpoint4
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your doctor may do blood tests to check your liver before you start taking zetia with a statin and during treatment.