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Capecitabine and its metabolites are predominantly excreted in urine95.5of administered capecitabine dose is recovered in urineFecal excretion is minimal2.6The major metabolite excreted in urine is FBAL which represents 57of the administered doseAbout 3of the administered dose is excreted in urine as unchanged drugThe elimination half-life of both parent capecitabine and 5-FU was about 0.75 hour.
XELODA may cause fetal harm when given to a pregnant womanCapecitabine caused embryolethality and teratogenicity in mice and embryolethality in monkeys when administered during organogenesisIf this drug is used during pregnancyor if a patient becomes pregnant while receiving XELODAthe patient should be apprised of the potential hazard to the fetussee Use In Specific Populations
The adverse reaction profile of capecitabine was consistent with the known adverse reaction profile in adultswith the exception cefadroxil 500 mg purchase. of laboratory abnormalities which occurred more commonly in pediatric patientsThe most frequently reported laboratory abnormalitiesper-patient incidence40were increased ALT75lymphocytopenia73leukopenia73hypokalemia68thrombocytopenia57hypoalbuminemia55neutropenia50low hematocrit50hypocalcemia48hypophosphatemia45and hyponatremia45
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