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The liver metabolizes methotrexate and later it is excreted in the urine.
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Before injection of methotrexate, the patient must be counseled extensively on the risks, benefits, and adverse effects of the treatment and on the possibility of failure of medical therapy, which would result in tubal rupture and necessitate surgery.
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Methotrexate treatment for cancer

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Methotrexate is an antimetabolite.
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