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One man reported a persistent urethral discharge that had failed to respond to previous therapy with oral cefixime.
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transient increases in bun1, 2, 41, 74 and serum creatinine concentrations and acute renal failure have been reported in less than 2 of patients receiving cefixime.
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differences in the pharmacokinetic parameters between 12 young and 12 elderly subjects who received 400 mg of cefixime once daily for 5 days are summarized as follows difference between age groups was significant.
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the serum half-life of cefixime in healthy subjects is independent of dosage from and averages 3 to 4 hours, but may range up to 9 hours in some normal volunteers.
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if cefixime were used to treat more than 58 of cases, then the level of cefixime resistance would become greater than 50 at the end of the 8-year simulation period, and if cefixime were used to treat all cases, resistance would be close to 100 .
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