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Ergot-containing drugs have been reported to cause prolonged vasospastic reactionsBecause there is a theoretical basis that these effects may be additiveuse of ergotamine-containing or ergot-type medicationslike dihydroergotamine or methysergideand rizatriptan within 24 hours is contraindicatedDue to an additive effectthe concomitant use of rizatriptan and ergotamine/ergot derivativesincluding methysergideincreases the risk of coronary artery vasoconstriction and hypertensive effectsThis combination is contraindicated.
GenderThe AUC of rizatriptan10 mg orallywas about 25lower in males as compared to femalesthe C max was 11lowerand the T max occurred at approximately the same timeThis apparent pharmacokinetic difference was of no clinical significance.
Dosing in pediatric patients is based on the patient’s body weightRIZACT Tablets 5mg is recommended in patients weighing less than 40 kg88 lband RIZACT Tablets 10mg in patients weighing 40 kg88 lbor more.
Patients with rare hereditary problems of galactose intolerancethe Lapp-lactase deficiency or glucose-galactose malabsorption should not take this medicine.
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