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The clearance of mirtazapine is reduced in elderly patients and in patients with moderate to severe renal or hepatic impairmentConsequentlythe prescriber should be aware that plasma mirtazapine levels may be increased in these patient groupscompared to levels observed in younger adults without renal or hepatic impairmentsee PRECAUTIONS and CLINICAL PHARMACOLOGY
REMERONmirtazapineTablets are contraindicated in patients with a known hypersensitivity to mirtazapine or to any of the excipients.
It is generally agreed that acute episodes of depression require several months or longer of sustained pharmacological therapy beyond response to the acute episodeSystematic evaluation of REMERONmirtazapineTablets has demonstrated that its efficacy in major depressive disorder is maintained for periods of up to 40 weeks following 8 to 12 weeks of initial treatment at a dose of 15 to 45 mg/daysee CLINICAL PHARMACOLOGYBased on these limited datait is unknown whether nolvadexcanada. or not the dose of REMERON needed for maintenance treatment is identical to the dose needed to achieve an initial responsePatients should be periodically reassessed to determine the need for maintenance treatment and the appropriate dose for such treatment.
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