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, the effect of chloramphenicol on rna and heme synthesis in bone marrow cultures.
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arylamine synthetase, the first enzyme involved in chloramphenicol biosynthesis, is repressed by the secreted chloramphenicol, by dl -p-aminophenylalanine and l -threo-p-aminophenylserinol.
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both esters are inactive, requiring hydrolysis to chloramphenicol for anti-bacterial activity.
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pecoul et al 54 have conducted a clinical trial to compare the efficacy at day 4 of a double intramuscular injection of long-acting chloramphenicol 100 mg kg with that of ampicillin administered intravenously for 8 days at 200 mg kg 4 times a day .
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