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In addition to reporting episodes of bleeding and easy bruisingpatients should be warned to promptly report any other signs which might also suggest the early development of blood dyscrasia such as pyrexia and sore throatA full blood count should be performed if infection is suspected or there is any other clinical evidence of blood dyscrasiaCilostazol should be discontinued promptly if there is clinical or laboratory evidence of haematological abnormalities.

Coadministration of stronge.gketoconazoleand moderatee.gerythromycindiltiazem and grapefruit juiceCYP3A4 inhibitors can increase exposure to PletalReduce Pletal atorvastatin 80 mg. dose to 50 mg twice daily when coadministered with strong or moderate inhibitors of CYP3A4see Dosage and Administration2.2and Clinical Pharmacology12.3

Cilostazol did not affect fertility or mating performance of male and female rats at doses as high as 1000 mg/kg/dayAt this dosesystemic exposuresAUCsto unbound cilostazol were less than 1.5 times in malesand about 5 times in femalesthe exposure in humans at the MRHD.

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There were no apparent trends toward a greater frequency of haemorrhagic adverse effects in patients taking cilostazol and ASA compared to patients taking placebo and equivalent doses of ASA.

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