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clopidogrel was not genotoxic in four in vitro tests ames test, dna-repair test in rat hepatocytes, gene mutation assay in chinese hamster fibroblasts, and metaphase chromosome analysis of human lymphocytes and in one in vivo test micronucleus test by oral route in mice.
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common and less severe side effects of clopidogrel bisulfate include pain in head and joints.
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a previous study concluded that measurement of clopidogrel bisulfate concentrations alone should not be a reliable method for bioequivalence assessment due to the very low concentrations, very small and variable values of auc, and high intrasubject variability.
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