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HYDREA is a cytotoxic drugFollow applicable special handling and disposal proceduressee REFERENCES
Reproductive System and Breast disordersazoospermiaand oligospermia Gastrointestinal disordersstomatitisnauseavomitingdiarrheaand constipation Metabolism and Nutrition disordersanorexiatumor lysis syndrome Skin and subcutaneous tissue disordersmaculopapular rashskin ulcerationdermatomyositis-like skin changesperipheral and facial erythemahyperpigmentationatrophy of skin and nailsscalingviolet papulesand alopecia Renal and urinary disordersdysuriaelevations in serum uric acidblood urea nitrogenBUNand creatinine levels Nervous system disordersheadachedizzinessdrowsinessdisorientationhallucinationsand convulsions General Disordersfeverchillsmalaiseedemaand asthenia Hepatobiliary disorderselevation of hepatic enzymescholestasisand hepatitis Respiratory disordersdiffuse pulmonary infiltratesdyspneaand pulmonary fibrosis.
HYDREA may cause macrocytosiswhich is self-limitingand is often seen early in the course of treatmentThe morphologic change resembles pernicious anemiabut is not related to vitamin B12 or folic acid deficiencyThis may mask the diagnosis of pernicious anemiaProphylactic administration of folic acid is recommended.
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