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Therapeutic results should be noticed after two to three weeks but more than six weeks of therapy may be required before definite beneficial effects are seen.
Tell each of your healthcare providers about all your medical conditionsallergiesand all medicines you use.
Therapeutic results should be noticed after two to three weeks but more than six weeks of therapy may be required before definite beneficial effects are seen.
Although the exact mode of action of tretinoin is unknowncurrent evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formationAdditionallytretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.
Laboratory findingsWhen laboratory mice are exposed to artificial sunlightthey often develop skin tumorsThese sunlight-induced tumors may appear more quickly and in greater number if the mouse is also topically treated with the active ingredient in RETIN-AtretinoinIn some studiesunder different conditionshoweverwhen mice treated with tretinoin were exposed to artificial sunlightthe incidence and rate of development of skin tumors was reducedThere is no evidence to date that tretinoin alone will cause the development of skin tumors in either laboratory animals or humansHoweverinvestigations in this area are continuing.
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skin treated with retin-a may be more vulnerable to these extremes.