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However, overexpression of serpina3n showed that antagonizing selective pathogenic proteases in the muscles of dystrophic mice is protective.
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AffiliationDepartment of Clinical BiochemistryHerlev HospitalCopenhagen University HospitalHerlevDenmark.
Impact of Common and Low-Frequent SERPINA1 Genetic Variants on AAT Serum Level.
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at the extracellular level, only the fully glycosylated 58 kda band corresponding to the mature protein was detected for serpina1, with expected differences in secretion levels of the different variants analyzed figure 1a .