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Rifampicina potent inducer of CYP3A4but also CYP2C8acts both as an inducer and inhibitor of the metabolism of repaglinideSeven days pre-treatment with rifampicin600 mgfollowed by co-administration of repaglinidea single dose of 4 mgat day seven resulted in a 50lower AUCeffect of a combined induction and inhibitionWhen repaglinide was given 24 hours after prednisone cheapest usa. the last rifampicin dosean 80reduction of the repaglinide AUC was observedeffect of induction aloneConcomitant use of rifampicin and repaglinide might therefore induce a need for repaglinide dose adjustment which should be based on carefully monitored blood glucose concentrations at both initiation of rifampicin treatmentacute inhibitionfollowing dosingmixed inhibition and inductionwithdrawalinduction aloneand up to approximately two weeks after withdrawal of rifampicin where the inductive effect of rifampicin is no longer presentIt cannot be excluded that other inducerse.gphenytoincarbamazepinephenobarbitalSt John’s wortmay have a similar effect.
If you have any further questions on the use of this medicineask your doctor or pharmacist.
Rememberthe cornerstone of diabetes control remains unchangedit is important to follow a meal plan and get plenty of exerciseDiabetes pills are simply another tool to help you manage your blood glucose.
Weight gaindiarrheaand joint pain may occurIf any of these effects persist or worsennotify your doctor or pharmacist promptly.
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