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In patients with JRA who are known or suspected to be poor CYP2C9 metabolizersconsider using alternative treatmentssee Use in Specific populationsand CLINICAL PHARMACOLOGY
When NSAIDs were administered with aspirinthe protein binding of NSAIDs were reducedalthough the clearance of free NSAID was not alteredThe clinical significance of this interaction is not knownSee Table 3 for clinically significant drug interactions of NSAIDs with aspirinsee DRUG INTERACTIONS
CELEBREX is not recommended in patients with severe renal insufficiencysee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY
In the APC trialthe hazard ratios compared to placebo for a composite endpointadjudicatedof cardiovascular deathmyocardial infarctionor stroke were 3.495CI 1.48.5with celecoxib 400 mg twice daily and 2.895CI 1.17.2with celecoxib 200 mg twice dailyCumulative rates for this composite endpoint over 3 years were 3.020/671 subjectsand 2.517/685 subjectsrespectivelycompared to 0.96/679 subjectswith placebo treatmentThe increases in both celecoxib dose groups versus placebo-treated patients were mainly due to an increased incidence of myocardial infarctionIn the PreSAP trialthe hazard ratio for sex power tablet name. this same composite endpointadjudicatedwas 1.295CI 0.62.4with celecoxib 400 mg once daily compared to placeboCumulative rates for this composite endpoint over 3 years were 2.321/933 subjectsand 1.912/628 subjectsrespectively.
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note overdose of generic celebrex should be avoided as it may lead to health complications.