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The correlation between findings of short-term endoscopic studies with CELEBREX and the relative incidence of clinically significant serious upper GI events with long-term use has not been establishedSerious clinically significant upper GI bleeding has been observed in patients receiving CELEBREX in controlled and open-labeled trialssee WARNINGS AND PRECAUTIONS and Clinical Studies

Advise females of reproductive potential who desire pregnancy that NSAIDsincluding CELEBREXmay be associated with a reversible delay in ovulationsee Use In Specific Populations

Celecoxib has been associated with anaphylactic reactions in patients with and without known hypersensitivity to celecoxib and in patients with aspirin sensitive asthmaCelebrex is a sulfonamide and both NSAIDs and sulfonamides may cause allergic type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible peoplesee CONTRAINDICATIONS and Exacerbation Of Asthma Related To Aspirin Sensitivity

An increase in the incidence of background findings of spermatocele with or without secondary changes such as epididymal hypospermia as well as minimal to slight dilation of the seminiferous tubules was seen in the juvenile ratThese reproductive findings while apparently treatment-related did not increase in incidence or severity with dose and may indicate an exacerbation canadian pharmacy brought by echeck. of a spontaneous conditionSimilar reproductive findings were not observed in studies of juvenile or adult dogs or in adult rats treated with celecoxibThe clinical significance of this observation is unknown.

This content has not been reviewed within the past year and may not represent WebMD’s most up-to-date information.

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i have decided to drop the celebrex because i no how hard it is on your heart and liver.