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Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statinsThe risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 may be increased with concomitant use of diltiazemWhen possibleuse a non-CYP3A4-metabolized statin together with diltiazemotherwisedose adjustments for both diltiazem and the statin should be considered along with close monitoring for signs and symptoms of any statin related adverse events.
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A 24-month study in rats and a 21-month study in mice showed no evidence of carcinogenicityThere was also no mutagenic response in in vitro bacterial testsNo intrinsic effect on fertility was observed in rats.
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cardizem cd, cartia xt, dilt-cd 180-240 mg day po; titrate after 14 days; maintenance range usually 180-420 mg day; not to exceed 480 mg day.