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bupropion was first synthesized by burroughs research in 1966, and patented by burroughs-wellcome later glaxo-wellcome in 1974.
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in a series of studies in healthy volunteers, ritonavir 100 mg twice daily or 600 mg twice daily or ritonavir 100 mg plus lopinavir kaletra 400 mg twice daily reduced the exposure of bupropion and its major metabolites in a dose dependent manner by approximately 20 to 80 .
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in animal experiments bupropion doses several times higher than therapeutic doses in humans caused, amongst others, the following dose-related symptoms ataxia and convulsions in rats, general weakness, trembling and emesis in dogs and increased lethality in both species.
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the mean elimination half-life sd of bupropion after chronic dosing is 21 9 hours, and steady-state plasma concentrations of bupropion are reached within 8 days.
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