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Thus, therapy with comparatively high doses of aminopenicillins such as ampicillin or amoxicillin 4-8g day for adults effectively helps to avoid the characteristic treatment failures or relapses of cervicofacial infections caused by a.

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Apart from the z allele, other common variants of serpina1 are described and include the m1, m2, and m3 alleles, linked to normal circulating protein levels; and the s allele, which results from the amino acid replacement e264v at the shutter region of the molecule 1 , 9 .