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The concomitant use of metformin with specific drugs may increase the risk of metformin-associated lactic acidosis those that impair renal function, result in significant homodynamic change, interfere with acid-base balance, or increase metformin accumulation.
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nifedipine a single-dose, metformin-nifedipine drug interaction study in normal healthy volunteers demonstrated that coadministration of nifedipine increased plasma glycomet c max and auc by 20 and 9 , respectively, and increased the amount excreted in the urine.
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